Transfusions, or known contact with anyone diagnosed with The patient denied a history of alcohol abuse, IDU, blood Serologic markers for hepatitis A, B, and C were negative, anti-HEV Serum samples included AST of 1262 U/L (normal:ġ5-37 U/L), total bilirubin of 5.5 mg/dL (normal: 0-1 mg/dL), andĪn alkaline phosphatase of 245 U/L (normal: 50-136 U/L). Physical examination revealed scleral icterus and a mildly tenderĪnd enlarged liver. Return to the United States, 1 week after onset of his symptoms, General malaise and subsequently had weight loss of 20 pounds. Approximately 4 weeks after hisĪrrival in India, he developed diarrhea, sore throat, fever, and India but lived in the United States since the age of 1 year, Margaritas with ice, they did not become ill, and serum samplesįrom all three were negative for anti-HEV.ĭuring June 1991, a high school student, who had been born in The patient recovered fully.Īlthough her three traveling companions also consumed Reported drinking margaritas with crushed ice at two restaurantsĪnd eating salsa and chips while in Mexico she denied drinking Infection for this patient was not clearly established, she The 6 months before onset of her illness. Transfusions, or contact with anyone known to have hepatitis during The patient had no underlying medical problems and deniedĮxcessive alcohol consumption, injecting-drug use (IDU), blood Respectively) and by a Western blot assay. Serum samples obtained onĪpril 18 and May 31 were positive for anti-HEV by fluorescentĪntibody (FA) blocking assay (titers of 1:512 and 1:128, Markers for hepatitis A, B, and C were negative, and an PhysicalĮxamination was normal except for jaundice. Total bilirubin level of 7.5 mg/dL (normal: 0-1 mg/dL). Obtained on March 23 demonstrated a serum aspartateĪminotransferase (AST) level of 2100 U/L (normal: 0-35 U/L), anĪlkaline phosphatase level of 516 U/L (normal: 110-295 U/L), and a On March 17, she developed headacheĪnd nausea, and on March 23, became jaundiced. On February 23, 1991, a woman from Denver traveled to Rosaritoīeach, Mexico, for 1 day (3). International travel - in four of these persons. This report summarizes CDC's serologic documentation ofĪcute HEV infection - presumed to have been acquired during Persons in the United States who had returned from international Setting and the exclusion of other causes of viral hepatitis.ĭuring 1989-1992, acute HEV infection was documented among six
Test was available to identify HEV infection, and diagnosisĭepended on a history of exposure in an appropriate epidemiologic To test for antibody to hepatitis E virus (anti-HEV), no serologic Recently, when research-based serologic tests (1,2) were developed Generally been related to contaminated water supplies. Non-B hepatitis) have occurred in some parts of the world and have Outbreaks of hepatitis E (i.e., enterically transmitted non-A, For assistance, please send e-mail to: Type 508 Accommodation and the title of the report in the subject line of e-mail. Persons using assistive technology might not be able to fully access information in this file.
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